Activity of Prosopis cineraria against N-nitrosodiethylamine induced liver tumors by regulating the levels of Tumor marker, Lipid peroxidation and Antioxidants

In this study, the activity of methanol extract of Prosopis cineraria (MPC) was evaluated in N-nitrosodiethylamine (DEN, 200mg/kg) induced experimental liver tumor in male Wistar rats. It was found that the administration of MPC (200 and 400mg/kg) effectively suppressed liver tumor induced by N-nitrosodiethylamine (DEN) as revealed by decrease in N-nitrosodiethylamine (DEN) induced elevated levels of alfa feto protein (AFP) and lipid peroxidation (LPO). The MPC extract also produced an increase in enzymatic antioxidants [superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] and non enzymatic antioxidants [Reduced Glutathione (GSH), Vitamin C and vitamin E] levels when compared to liver tumor bearing animals. Our data suggests that MPC may extend its chemopreventive effect by modulating the levels of alfa feto protein and lipid peroxidation and augmenting antioxidant defense system.